Antibacterial cream formulation of ethanolic Pliek U extracts and ethanolic residue hexane Pliek U extracts against Staphylococcus aureus

Abstract

Indonesia as the largest archipelago country in the world is also known as a country with plenty of natural resources that can be used as traditional medicinal plants. Pliek U is a fermented crude coconut meat has been used as an ingredient in Aceh traditional food and also used as a traditional topical medicine in Aceh. Pliek U is potential as a source of free fatty acids (FFAs) such as lauric acid and monolauric acid which have antimicrobial properties. The aim of this study is to determine the activity ethanolic Pliek U extracts (EPUE) and ethanolic of residue hexane of Pliek U extracts (ERHPUE) and also the activities of their cream formulation against Staphylococcus aureus The antibacterial activity was determined by disc difussion method with clindamycin as a positive control. The antibacterial activity results showed that EPUE has antibacterial activity against Staphylococcus aureus with diameter inhibition zone of 8.66 0.57 mm, while ERHPUE and their cream have no activity against Staphylococcus aureus.