Currently, there are a large number of reports about the development of autoimmune conditions after COVID-19. Also, there have been cases of sarcoid-like granulomas in convalescents as a part of the post-COVID-19 syndrome. Since one of the etiological theories of sarcoidosis considers it to be an autoimmune disease, we decided to study changes in the adaptive humoral immune response in sarcoidosis and SARS-CoV-2 infection and to find out whether COVID-19 can provoke the development of sarcoidosis. This review discusses histological changes in lymphoid organs in sarcoidosis and COVID-19, changes in B cell subpopulations, T-follicular helper cells (Tfh), and T-follicular regulatory cells (Tfr), and analyzes various autoantibodies detected in these pathologies. Based on the data studied, we concluded that SARS-CoV-2 infection may cause the development of autoimmune pathologies, in particular contributing to the onset of sarcoidosis in convalescents.
CITATION STYLE
Rubinstein, A., Kudryavtsev, I., Malkova, A., Mammedova, J., Isakov, D., Isakova-Sivak, I., … Starshinova, A. (2023). Sarcoidosis-related autoimmune inflammation in COVID-19 convalescent patients. Frontiers in Medicine. Frontiers Media SA. https://doi.org/10.3389/fmed.2023.1271198
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