Enhanced Neuroprotection by Local Intra-Arterial Infusion of Human Albumin Solution and Local Hypothermia

Abstract

Background and Purpose-: We investigated the potential benefit of using a local infusion of low-dose and cold human albumin in ischemic rats as compared with systemic delivery. Methods-: Stroke was induced in rats, and at 2 hours treatment groups received 0 C saline or low-dose albumin at 0 C or 37 C infused into the ischemic area. Results-: The local low-dose cold albumin infusion, which achieved the hypothermic temperature (P<0.001), produced the greatest reduction in infarct volume and the best recovery of neurological function. Conclusions-: The local low-dose cold albumin infusion into the ischemic area offered a combination of regional brain hypothermia and albumin administration, which enhanced neuroprotection and would be beneficial in the clinical setting. © 2012 American Heart Association, Inc.