NCMP-20. TUMOR TYPES, RESECTION AND INCIDENCE OF NEUROPATHY: CURRENT LITERATURE REVIEW

Abstract

PURPOSE: By identifying the individual sub-categorical phenotypes most associated with neuropathy and collectively using to specify a single tumor most associated with neuropathy, the hopes of this literature review are to help clinicians begin treatment for neuropathy before symptoms become severe and perhaps prevent it to the best of their ability. METHODS: All clinical studies and literature reviews analyzed in this review were obtained through PubMed Central from 1990 through 2017. Characteristics included shape, size, location, approximate estimation of growth period, presence and occurrence of metastasis, and original location of tumor. After a thorough consideration of these characteristics, the specific phenotypes of the tumor for each of these categories most likely to result in any form of neuropathy was determined. Furthermore, the individual subcategory phenotypes were then aggregated to characteristically specify a single tumor most associated with severe neuropathy. RESULTS: The most commonly affected regions of peripheral nerves were analyzed to give better idea of which regions of tumor incidence would be most affiliated with an eventual onset of neuropathy. So certain degree of preventative measures and follow-up with the patient frequently due to the knowledge that neuropathy is very likely to occur. Certain chemotherapies were found to be associated with the most cases of neuropathy. Lung and Breast was found to lead to the most cases of neuropathy. These two cancers were also found to be most associated with brain metastasis which further sheds light on why neuropathy and paraneoplastic disease is occurring in patients with these forms of cancer. CONCLUSIONS: Through a detailed analysis of cancers most associated with neuropathy and paraneoplastic disease, a certain guidelines and risk factors were generated to help prepare for neuropathy following diagnosis of cancers. The warning guideline includes form of chemotherapy, the presence of lung or breast cancer, signs of brain metastasis.