Impact of drug-eluting stents on distal vessels

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Abstract

Background-Previous studies have not addressed vessel response >5 mm distal to the stent edge. Therefore, we investigated the impact of paclitaxel-eluting stents (PES) versus bare metal stents (BMS) on distal vessels in the serial intravascular ultrasound substudies of TAXUS IV, V, and VI. Methods and Results-TAXUS IV, V, and VI were double-blind, randomized, multicenter, controlled trials comparing PES with BMS. In their intravascular ultrasound substudies, 103 patients (54 BMS, 49 PES) had intravascular ultrasound data ≥10 mm distal to the stent both postprocedure and at 9 months follow-up. Baseline characteristics were similar between the 2 groups. Multilevel modeling was used to account for the variation between patients and within patients among distal segments. Effect of stent type, time, and their interaction was tested using a mixed effect model controlling for distal segments. Postprocedure lumen and vessel were not significantly different between PES versus BMS; however, lumen (P=0.006) and vessel (P=0.0001) were significantly reduced for BMS at 9-month follow-up but not for PES. Conversely, there was a significant plaque increase from postprocedure to 9-month follow-up for PES (P=0.0008) but not for BMS. These vessel responses were statistically consistent among 0- to 5-mm versus 5- to 10-mm versus 10- to 15-mm segments distal to the stent in both groups. Conclusions-PES use was associated with plaque increase from baseline to 9-month follow-up >5 mm distal to the stent along with positive remodeling, whereas BMS use was associated with negative remodeling and no plaque increase. These vessel responses were consistent in 5-mm long subsegments: 0 to 5 mm versus 5 to 10 mm versus 10 to 15 mm distal to the stent. Clinical Trial Registration-URL: http://www.clinicaltrial.gov. Unique identifiers: TAXUS IV-NCT00292474; TAXUS V-NCT00301522; TAXUS VI-NCT00297804. © 2012 American Heart Association, Inc.

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CITATION STYLE

APA

Wakabayashi, K., Mintz, G. S., Weissman, N. J., Stone, G. W., Ellis, S. G., Grube, E., … Waksman, R. (2012). Impact of drug-eluting stents on distal vessels. Circulation: Cardiovascular Interventions, 5(2), 211–219. https://doi.org/10.1161/CIRCINTERVENTIONS.111.965780

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