Abstract
The Central Brain Tumor Registry of the USA estimates the annual incidence of primary brain and central nervous system (CNS) tumors at 7.3/100,000 for malignant and 13.3/100,000 for nonmalignant tumors. A true comparison of incidence numbers across different time periods and countries is difficult given the inconsistency of data collection methods and the diversity in diagnostic criteria. Available diagnosis rates for malignant gliomas spanning the last three decades do not allow the determination of an increase or decline of age adapted incidence (Ohgaki and Kleihues, Acta Neuropathol 109:93-108, 2005; Ostrom et al., Neuro Oncol 16:896-913, 2014), despite remarkable changes of environment and lifestyle in industrial nations.
Author supplied keywords
- Brain tumor growth
- Cell cycle dysregulation
- Central nervous system tumor syndromes
- Cowden syndrome and Lhermitte-Duclos disease
- Ependymoma
- Gorlin syndrome
- Human brain tumors
- Medulloblastoma
- Mitogenic factors
- Neuroepithelial human brain tumors
- Neurofibromatosis type 1
- Neurofibromatosis type 2
- Tuberous sclerosis complex
- Turcot syndrome
- von Hippel-Lindau syndrome
Cite
CITATION STYLE
Coluccia, D., Weeks, A., Fandino, J., Schneider, C., Smith, C., & Rutka, J. T. (2016). Molecular biology of human brain tumors. In The Molecular Basis of Human Cancer (pp. 657–694). Springer New York. https://doi.org/10.1007/978-1-59745-458-2_35
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