Suppression of centrosome duplication and amplifcation by deacetylases

Abstract

Centrosome duplication is controlled both negatively and positively by a number of proteins. the activities and stabilities of those regulatory proteins are in many cases controlled by posttranslational modifcations. Although acetylation and deacetylation are highly common posttranslational modifcations, their roles in the regulation of centrosome duplication had not been closely examined. Here, through focusing on the deacetylases, we investigated the role of acetylation/deacetylation in the regulation of centrosome duplication and induction of abnormal amplifcation of centrosomes. We found that the deacetylation event negatively controls centrosome duplication and amplifcation. Of the 18 total known deacetylases (HDAC1-11, SIRT1-7), ten deacetylases possess the activity to suppress centrosome amplifcation, and their centrosome amplifcation suppressing activities are strongly associated with their abilities to localize to centrosomes. Among them, HDAC1, HDAC5 and SIRt1 show the highest suppressing activities, but each of them suppresses centrosome duplication and/or amplifcation with its unique mechanism. © 2012 Landes Bioscience.