Simulation of equilibrium and dynamic properties of large DNA molecules

Abstract

The review considers computer simulation of DNA large-scale equilibrium and dynamic properties. Much attention is paid to DNA models used in the simulations and the choice of the model parameters. The Monte Carlo procedure for simulation of DNA equilibrium properties and Brownian dynamic simulation of DNA movement in solution are described for both linear and circular DNA molecules. Accuracy of the simulations is addressed by comparing measured and computed properties of the molecules. © 2006 Springer.