What-about-the-neutrophils-phenotypes

Abstract

Human neutrophils are in the sights of immunology, since recent research has positioned them as new players in adaptive immunity besides innate immunity. These leukocytes not only limit their function to phagocytosis, production of reactive oxygen species and generation of neutrophil extracellular traps, but also modulate the immune response according to the microenvironment and the cell-cell interactions, such as interactions between neutrophils, T cells and macrophages. This review summarizes current polymorphonuclear neutrophils research on some phenotypes in scientific literature in murine and human models.