BRCA1 and p53 tumor suppressor molecules in Alzheimer’S disease

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Abstract

Tumor suppressor molecules play a pivotal role in regulating DNA repair, cell proliferation, and cell death, which are also important processes in the pathogenesis of Alzheimer’s disease. Alzheimer’s disease is the most common neurodegenerative disorder, however, the precise molecular events that control the death of neuronal cells are unclear. Recently, a fundamental role for tumor suppressor molecules in regulating neurons in Alzheimer’s disease was highlighted. Generally, onset of neurodegenerative diseases including Alzheimer’s disease may be delayed with use of dietary neuro-protective agents against oxidative stresses. Studies suggest that dietary antioxidants are also beneficial for brain health in reducing disease-risk and in slowing down disease-progression. We summarize research advances in dietary regulation for the treatment of Alzheimer’s disease with a focus on its modulatory roles in BRCA1 and p53 tumor suppressor expression, in support of further therapeutic research in this field.

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Nakanishi, A., Minami, A., Kitagishi, Y., Ogura, Y., & Matsuda, S. (2015). BRCA1 and p53 tumor suppressor molecules in Alzheimer’S disease. International Journal of Molecular Sciences, 16(2), 2879–2892. https://doi.org/10.3390/ijms16022879

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