Abstract
The human CR1 is a single chain membrane glycoprotein that is a member of the group of regulators of the complement activation system. In order to clarify the regulatory mechanisms of human CR1 gene expression, the 5'-flanking region of the human CR1 gene was isolated and its promoter was characterized. The CR1 expression was found to be transcriptionally up-regulated in HL60 cells by stimulation with DMSO. The cloned CR1 gene promoter was sequenced and computer analyzed. The potential promoter region lacks a distinct TATA box sequence. The transcription initiation site was determined by primer extension and several possible regulatory elements for transcription were found in the promoter region.
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Kim, J. H., Lee, S., & Choe, S. Y. (1999). Characterization of the human CR1 gene promoter. Biochemistry and Molecular Biology International, 47(4), 655–663. https://doi.org/10.1080/15216549900201713
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