Electron paramagnetic resonance - A powerful tool of medical biochemistry in discovering mechanisms of disease and treatment prospects

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Abstract

In pathophysiological conditions related to oxidative stress, the application of selected antioxidants could have beneficial effects on human health. Electron paramagnetic resonance (EPR) spectroscopy is a technique that provides unique insight into the redox biochemistry, due to its ability to: (i) distinguish and quantify different reactive species, such as hydroxyl radical, superoxide, carbon centered radicals, hydrogen atom, nitric oxide, ascorbyl radical, melanin, and others; (ii) evaluate the antioxidative capacity of various compounds, extracts and foods; (iii) provide information on other important parameters of biological systems. A combination of EPR spectroscopy and traditional biochemical methods represents an efficient tool in the studies of disease mechanisms and antioxidative therapy prospects, providing a more complete view into the redox processes in the human organism.

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Spasojević, I. (2010, July 1). Electron paramagnetic resonance - A powerful tool of medical biochemistry in discovering mechanisms of disease and treatment prospects. Journal of Medical Biochemistry. https://doi.org/10.2478/v10011-010-0020-0

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