Carbamate derivatives and sesquiterpenoids from the South China Sea gorgonian Melitodes squamata

Abstract

Five carbamate derivatives,obtucarbamates C and D (1, 2),dimethyl ((carbonylbis(azanediyl))bis(2-methyl-5,1-phenylene))dicarbamate(3), obtucarbamates A and B (4, 5),and four aromadendrane-type sesquiterpenoids,(+)- 4β-N-methenetauryl-10β-methoxy- 1β,5α,6β,7β- aromadendrane (6), (-)-4β-N-methenetauryl-10β-methoxy-1β,5β, 6α,7α-aromadendrane (7), (-)-4α,10β-aromadendranediol (8),(+)-4β,10β-aromadendranediol (9) were obtained from the South China Sea gorgonian coral Melitodes squamata Nutting. Compounds 1,2,6, and 7 were new,and their structures were established by spectroscopic analyses.Compounds 6 and 7 contained a taurine group that was rarely found in marine natural compounds, and 7 showed moderate antibacterial activity. The possible biosynthesis routes of 1-5 were conjectured. © 2012 Huang et al. licensee Beilstein-Institut.