New horizons in clinical immunology: applications of induced pluripotent stem cells for the analysis of immune disorders

Abstract

The discovery of induced pluripotent stem cells (iPSCs) has diversified approaches to studies of human diseases. iPSCs can be used in regenerative medicine and for the analysis of the pathogenesis of hereditary diseases. They can also be applied to research on immune disorders, including the influence of genetic factors on autoimmune diseases in the human system. Some immune cells, such as dendritic cells and macrophages, can be differentiated from iPSCs. Thus, immune disorders caused by defects in the innate immune system can be studied with that approach. We propose that biological mechanisms of genetic risks could be examined by mutating or modifying disease-susceptibility genes in iPSCs by genome editing. Studies using human iPSCs are also expected to elucidate the underlying pathogenesis of immunological diseases and new approaches to drug discovery.