PCOS: Implications of Cardiometabolic Dysfunction

Abstract

Polycystic ovary syndrome (PCOS) represents the most common endocrine disorder in women of reproductive age with a reported incidence of 6–15%, depending on the criteria used for defining this heterogeneous condition [1–4]. According to the Rotterdam criteria, at least two of the three following features must be present: ovulatory dysfunction, clinical or biochemical hyperandrogenism and polycystic ovarian morphology [2, 3]. Other possible underlying pathologies must be excluded. Familial clustering of this heterogeneous condition has clearly been shown although the aetiology and the genetic determinants of PCOS remain uncertain [5–7]. Needs for medical intervention in women with PCOS vary significantly depending on the stage of life (Fig. 10.1).