Abnormal haemoglobin levels in acute coronary syndromes

26Citations
Citations of this article
39Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Background: Anaemia is an adverse prognostic marker in acute coronary syndromes (ACS), but the epidemiology of abnormal haemoglobin levels in such patients is uncertain. Aims: To investigate the prevalence, natureand predictors of abnormal haemoglobin levels in ACS patients at admission. Design: Observational study. Methods: All emergency admissions from January to April 2005 were assessed within 24-48 h of hospital admission. ACS patients (unstable angina, non-ST-elevation or ST-elevation myocardial infarction) were enrolled (n = 320, 190 men). Clinical information was recorded. Results: Overall, 71% had unstable angina; 18% non-ST-elevation myocardial infarction (MI), and 11% ST-elevation MI. Mean ± SD haemoglobin was 14.3 ± 1.7 g/dl in men and 13.2 ± 1.5 g/dl in women. Abnormal haemoglobin was more common in men (65, 34%) than in women (34, 22%) (p = 0.013). Anaemia (haemoglobin <13 g/dl in men, or <12.0 g/dl in women) was recorded in 35 (18%) men and 24 (18%) women. All had admission haemoglobin >8 g/dl, and anaemia was usually normocytic. Multivariate predictors of anaemia (OR, 95%CI) were age (1.07, 1.04-1.1) and serum albumin (0.90, 0.81-1.00). Elevated haemoglobin (>16 g/dl) was recorded in 30 (16%) men and 4 (3%) women (p < 0.01), and was more common in ST-elevation MI patients (26%) than in unstable angina or non-ST elevation MI patients (9%) (p = 0.005). In patients who underwent invasive management with a post-procedure haemoglobin the following day (n = 85), 15 (18%) new cases of anaemia were detected. Admission duration correlated with haemoglobin (p < 0.01), creatinine (p < 0.01), troponin I (p < 0.01) and C-reactive protein (p < 0.01). Anaemia was more common in those who died in hospital (3, 60%) than in those who survived (56, 18%) (adjusted p = 0.0135). Discussion: Abnormal haemoglobin levels were common in our ACS admissions. Anaemia was generally mild. Increasing age and interventional management were associated with anaemia, which in turn was associated with adverse in-hospital outcomes. Interventions to prevent and detect anaemia in this setting merit prospective testing. © 2006 Oxford University Press.

References Powered by Scopus

Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation

6296Citations
N/AReaders
Get full text

Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: The PCI-CURE study

3144Citations
N/AReaders
Get full text

The TIMI risk score for unstable angina/non-ST elevation MI: A method for prognostication and therapeutic decision making

2814Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Mechanisms linking red blood cell disorders and cardiovascular diseases

130Citations
N/AReaders
Get full text

Impact of Blood Transfusion on Short- and Long-Term Mortality in Patients With ST-Segment Elevation Myocardial Infarction

64Citations
N/AReaders
Get full text

Anemia for Risk Assessment of Patients With Acute Coronary Syndromes

58Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Bindra, K., Berry, C., Rogers, J., Stewart, N., Watts, M., Christie, J., … Eteiba, H. (2006). Abnormal haemoglobin levels in acute coronary syndromes. QJM: An International Journal of Medicine, 99(12), 851–862. https://doi.org/10.1093/qjmed/hcl117

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 13

52%

Researcher 7

28%

Professor / Associate Prof. 5

20%

Readers' Discipline

Tooltip

Medicine and Dentistry 24

83%

Agricultural and Biological Sciences 3

10%

Neuroscience 1

3%

Social Sciences 1

3%

Save time finding and organizing research with Mendeley

Sign up for free