Hepatoprotective efficacy of edible macrofungi Dacryopinax spathularia (Schwein) and Schizophyllum commune (Fries) against Carbon tetrachloride induced hepatotoxicity in albino Wistar rats

Abstract

In the present study the hepatoprotective efficacy of two edible macrofungi Dacryopinax spathularia and Schizophyllum commune has been assessed against CCl4-induced hepatotoxicity in albino wistar rats. The administration of CCl4(1ml/Kg) resulted into significant (p<0.05) rise in the levels of liver function marker enzymes Alanine Transaminase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP) and bilirubin and decrease in the levels of total protein and albumin in blood. On administration of low dose (250mg/Kg) and high dose (500mg/Kg) of both macrofungal extracts in different hepatotoxic group of rats, the serum levels of AST, ALT, ALP and bilirubin significantly (p<0.05) lowered down and the levels of total protein and albumin significantly (p<0.05) increased in comparison to the hepatotoxic group of rats, reflecting the hepatoprotective impact of both the extracts.