fMRI studies of sensitivity and habituation effects within the auditory cortex at 1.5 T and 3 T

Abstract

Purpose: To assess habituation effects in relation to field strength by fMRI at 1.5 vs. 3.0 T within the auditory cortex of healthy subjects. Materials and Methods: fMRI experiments were performed on 19 healthy subjects at 1.5 T (N = 12) and 3 T (N = 12). The auditory cortex was stimulated binaurally by digitally generated pulsed (ν = 5 Hz) 800 Hz sine tones with three alternating on and off periods. Results: The mean activation after stimulation (4.4% ± 1.2% (1.5 T) and 5.3% ± 2.3% (3 T)) and number of activated pixels (96.7 ± 49.8 (1.5 T) and 139.9 ± 101 (3T)) were higher at 3 T compared to 1.5 T; however, that difference did not reach statistical significance. A characteristic signal decay with repeated stimuli was revealed at both 1.5 and 3 T, and the response to the second and third stimulation blocks was significantly lower compared to the first. The habituation pattern was the same, independently of field strength and age. Conclusion: The mean activation and number of pixels were only modestly higher at 3 T, probably due to higher physiologic noise and higher local macroscopic susceptibility gradients within the temporal lobes at 3 T. Our data reveal that measured auditory habituation is independent of field strength, and data obtained at two different field strengths do not differ fundamentally in this context. © 2006 Wiley-Liss, Inc.