Sesquiterpene aminoquinones, from a marine sponge, induce erythroid differentiation in human chronic myelogenous leukemia, K562 cells

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Abstract

A new sesquiterpene aminoquinone, 5-epi-smenospongorine, together with nine known sesquiterpene quinone/phenols, was isolated as differentiation-inducing substances to K562 cells into erythroblast from the marine sponge Dactylospongia elegans. The structure-activity relationship study of these compounds clarified that the quinone skeleton is indispensable and the amino group plays an important role for their differentiation-inducing activity to K562 cells into erythroblast. © 2004 Pharmaceutical Society of Japan.

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Aoki, S., Kong, D., Matsui, K., Rachmat, R., & Kobayashi, M. (2004). Sesquiterpene aminoquinones, from a marine sponge, induce erythroid differentiation in human chronic myelogenous leukemia, K562 cells. Chemical and Pharmaceutical Bulletin, 52(8), 935–937. https://doi.org/10.1248/cpb.52.935

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