Preferential swelling and vacuolation of dendrites were observed electron microscopically in different brain regions of rats treated with LiCl in a dose of 6-18 mmol/kg for 1-6 days. The most severe fine structural changes were revealed in the hippocampus. Low-dose (0.33 mmol/kg) lithium treatment lasting for a year did not cause any morphologically detectable alterations in the rat brain. In vitro studies showed a reduction of dendro-axonal process network of neurons measured by morphometric means after lithium exposure. Using different cultures of neuronal and glial cell populations, higher lithium uptake was observed for neuron-enriched cultures.
CITATION STYLE
Janka, Z., Szentistvanyi, I., Kiraly, E., Parducz, A., Juhasz, A., & Joo, F. (1981). Preferential vulnerability of dendrites to lithium ion in rat brain and in nerve cell culture. Acta Neuropathologica. Supplementum, 7, 44–47. https://doi.org/10.1007/978-3-642-81553-9_13
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