The Effect of Cd (II) Metal Ion Induction to Organ Experiment Rats

Abstract

Cd (II) is a hazardous compound with high toxicity. Cadmium toxicity contributes to a large number of health problems, including diseases that are the primary killers of heart disease, cancer and diabetes. The ability of Cd (II) to produce free radicals can cause a damaging effect on plasma lipids and lipoproteins through lipid oxidation and contribute to the ability of Cd (II) to produce effects on the cardiovascular system. This study aims to investigate distribution of Cd (II) in various organs through in vivo model using rats as a sample. The method used in this study is the Batch system. Using 6 rats as samples, which were divided into 2 groups. The first group as a control and remain group act as Cd (II) group (Injected by 1000 mg/L). The highest until the lowest level of Cd (II) are the liver (45.66 x 10-3 mg/g), lungs (34.16 x 10-3 mg/g), kidney (11.75 x 10-3 mg/g) and spleen (6. 11 x 10-3 mg/g), respectively. From this study it can be concluded that the highest accumulation Cd (II) in the liver and lowest level was in spleen.