Metabolic Cross Talk Between Cancer Cells and Tumor Microenvironment

Abstract

An obscure metabolic network controls the activities of the cancer cells and their microenvironment which still continues to be unraveled. Cancer cells modify the biochemistry of the extracellular environment, which bring about multiple consequences on the phenotypes of non-tumor cells residing in the close vicinity of the tumor and also the extracellular matrix. Reciprocally, metabolism and the signaling feedback of cancer cells are affected by the microenvironment. Here we discuss our existing understanding of alterations in metabolism during cancer progression and how metabolic cross talk between cancer cells and their so-called microenvironment is affected during this process.