Controlled by a strict mechanism, intracellular calcium (Ca(2+)) is closely related to various cellular activities, including the regulation of autophagy. Researchers believed that under normal or stress state, Ca(2+) has a positive or negative regulation effect on autophagy, the mechanisms of which are different. This bidirectional role of Ca(2+), promotive or suppressing in the regulation of autophagy under different conditions remains controversial, so as the potential mechanisms. Several studies reported that Ca(2+) promotes autophagy through plenty of ways, like inositol 1,4,5-trisphosphate receptor (IP3R) and beclin1 pathway, calmodulin-dependent kinase kinase beta (CaMKKβ)–AMPK–mTOR pathway, mitochondrial energy metabolism-related Ca(2+) uptake, lysosome’s regulation of Ca(2+) signal, and so on. Others thought Ca(2+) may inhibit autophagy through IP3R and beclin1–Bcl-2 complex and the AMPK–mTOR pathway, either. It seems to be still a long way to thoroughly understand the truth of Ca(2+) and autophagy.
CITATION STYLE
Hu, Y. X., Han, X. S., & Jing, Q. (2019). Ca(2+) Ion and Autophagy. In Advances in Experimental Medicine and Biology (Vol. 1206, pp. 151–166). Springer. https://doi.org/10.1007/978-981-15-0602-4_7
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