Molecular Parameters for Prognostic and Predictive Assessment in Colorectal Cancer

Abstract

Over the last several years, a large amount of information has been obtained on the molecular and genetic characteristics of colorectal cancer, especially related to the mechanisms of cancer development, invasion, metastasis and response to therapy. Part of this information can be translated into useful molecular testing, which might assist the clinician in classifying patients more effectively and developing personalized therapies. Here we review the molecular characteristics of colorectal cancer, with the specific purpose of highlighting those features currently known to possess prognostic or predictive value.