Although the literature concerning statistical testing for genotype-phenotype association in family-based and population-based studies is very extensive, until recently the sex chromosomes have received little attention. Here it is shown that the X chromosome in particular presents special problems with respect to efficient analysis of mixed-sex population studies, and as a result of X inactivation. This paper reviews recent developments in approaching these problems. © 2009 BioMed Central Ltd.
CITATION STYLE
Clayton, D. G. (2009, November 24). Sex chromosomes and genetic association studies. Genome Medicine. https://doi.org/10.1186/gm110
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