Cardiac tissue engineering using human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) has facilitated the creation of in vitro diagnostic platforms to study novel small molecules and cardiac disease at the tissue level. Yet, due to the immaturity of hPSC-CMs, there is a low fidelity between tissue-engineered cardiac tissues and adult cardiac tissues. To address this challenge, we have developed a platform that combines both physical and electrical cues to guide hPSC-CMs towards a more mature state in vitro. © 2014 Springer Science+Business Media New York.
CITATION STYLE
Miklas, J. W., Nunes, S. S., Zhang, B., & Radisic, M. (2014). Design and fabrication of biological wires. Methods in Molecular Biology, 1181, 157–165. https://doi.org/10.1007/978-1-4939-1047-2_14
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