Recent studies have reported that COVID-19 patients with lung cancer have a higher risk of severe events than patients without cancer. In this study, we investigated the gene expression of angiotensin I-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) with prognosis in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Lung cancer patients in each age stage, subtype, and pathological stage are susceptible to SARS-CoV-2 infection, except for the primitive subtype of LUSC. LUAD patients are more susceptible to SARS-CoV-2 infection than LUSC patients. The findings are unanimous on tissue expression in gene and protein levels.
CITATION STYLE
Kong, Q., Xiang, Z., Wu, Y., Gu, Y., Guo, J., & Geng, F. (2020). Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection. Molecular Cancer, 19(1). https://doi.org/10.1186/s12943-020-01209-2
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