Prevention of vertical (i.e., mother-to-child) transmission of HIV is essential to reduce significant HIV-related child morbidity and mortality in developing countries. Globally, pediatric infections comprise about 15% of all new HIV infections each year and virtually all pediatric infections can be prevented by eliminating vertical transmission [1]. The World Health Organization (WHO) recommendations (revised in 2006) for prevention of mother-to-child transmission (PMTCT) 1 include a four-pronged comprehensive strategy [2]. Although we acknowledge the critical role that all approaches play in reducing pediatric HIV infection, the focus of this chapter is on strategies that address the third prong: preventing HIV transmission from infected mothers to their infants. Considerable achievements have been made on this front, including many clinical trials demonstrating good efficacy. © 2011 Springer Science+Business Media, LLC.
CITATION STYLE
Wilfert, C. M., Sripipatana, T., Spensley, A., Kieffer, M. P., & Bitarakwate, E. (2011). Prevention of vertical transmission of HIV in resource-limited countries. Advances in Experimental Medicine and Biology, 697, 41–57. https://doi.org/10.1007/978-1-4419-7185-2_4
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