Developing a general strategy for the solid supported synthesis of heterocycles: Applications to the generation of molecular diversity and drug discovery

Abstract

The development of a general strategy for the generation of molecular diversity in the form of novel, non-amide based heterocyclic structures is described. The generation of diverse peptide and peptidomimetic libraries, the automation of these strategies and computational approaches to diversity generation are also discussed. The main focus of this lecture is the the progression of these concepts into a strategy for small molecule library generation, and hence the generation of small molecule therapeutic leads.