Abnormal fucosylation of ileal mucus in cystic fibrosis: I A histochemical study using peroxidase labelled lectins

18Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.

Abstract

Peroxidase conjugated lectins were used to analyse the glycoproteins of small intestinal mucins in normal infants and those with cystic fibrosis to ascertain whether there are any detectable histochemical differences in saccharide composition. A significant decrease in Lotus tetragonolobus (LTG) binding fucose was shown in normal small intestinal mucin starting around 36 weeks' gestation with total absence of staining at term and beyond. In contrast, the age matched patients with cystic fibrosis showed persistent and intense LTG binding of fucose. These results provide the first clear histochemical evidence that cystic fibrosis mucin is abnormal and confirm the findings of previous biochemical studies.

Cite

CITATION STYLE

APA

Thiru, S., Devereux, G., & King, A. (1990). Abnormal fucosylation of ileal mucus in cystic fibrosis: I A histochemical study using peroxidase labelled lectins. Journal of Clinical Pathology, 43(12), 1014–1018. https://doi.org/10.1136/jcp.43.12.1014

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free