Fijimycins A-C, three antibacterial etamycin-class depsipeptides from a marine-derived Streptomyces sp.

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Abstract

Three new depsipeptides, fijimycins A-C (1-3), together with the known etamycin A (4), were isolated and identified from the fermentation broth of strain CNS-575, a Streptomyces sp. cultured from a marine sediment sample collected off Nasese, Fiji. The planar structures of the new fijimycins were assigned by combined interpretation of NMR and MS/MS spectroscopic data. These assignments were complicated by the fact that 1-3 occurred as complex amide conformational mixtures. The absolute configurations of the component amino acids were established using the Marfey's method. Fijimycins A-C, and etamycin A, were shown to possess significant in vitro antibacterial activity against three methicillin-resistant Staphylococcus aureus (MRSA) strains with MIC 100 values between 4 and 16 μg mL -1. © 2011 Elsevier Ltd. All rights reserved.

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Sun, P., Maloney, K. N., Nam, S. J., Haste, N. M., Raju, R., Aalbersberg, W., … Fenical, W. (2011). Fijimycins A-C, three antibacterial etamycin-class depsipeptides from a marine-derived Streptomyces sp. In Bioorganic and Medicinal Chemistry (Vol. 19, pp. 6557–6562). https://doi.org/10.1016/j.bmc.2011.06.053

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