Functional and pharmacological characterization of a Shal-related K + channel subunit in Zebrafish

1Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

Abstract

BACKGROUND: K+ channels are diverse; both in terms of their function and their molecular composition. Shal subunits were first described in Drosophila. There are three mammalian orthologs, which are members of the Kv4 subfamily. They are involved in neuronal firing patterns as well as control of the cardiac action potential duration. RESULTS: Here, we report the biophysical and pharmacological characterization of zShal3, which is the ortholog of the mammalian Kv4.3 subunit, which in mammals is involved in action potential repolarization and gives rise to neuronal A-type K+ currents involved in somatodendretic signal integration. CONCLUSION: We demonstrate that zShal has similar functional and pharmacological characteristics compared to Kv4.3 and it is similarly regulated by pharmacological agents and by the Kv4 accessory subunit, NCS-1.

Cite

CITATION STYLE

APA

Nakamura, T. Y., & Coetzee, W. A. (2008). Functional and pharmacological characterization of a Shal-related K + channel subunit in Zebrafish. BMC Physiology, 8(1). https://doi.org/10.1186/1472-6793-8-2

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free