Endonucleolytic cleavage of Holliday junctions is important in recombination and replication. Mus81 proteins in yeasts and humans appear to have many, but not all, of the expected properties of eukaryotic Holliday junction resolvases, with intriguing connections to DNA replication checkpoints.
Haber, J. E., & Heyer, W. D. (2001, November 30). The fuss about Mus81. Cell. Cell Press. https://doi.org/10.1016/S0092-8674(01)00593-1