G2/M cell cycle arrest in the life cycle of viruses

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There is increasing evidence that viral infection, expression of viral protein or the presence of viral DNA causes the host cell cycle to arrest during G2/M. The mechanisms used by viruses to cause arrest vary widely; some involve the activation of the cellular pathways that induce arrest in response to DNA damage, while others use completely novel means. The analysis of virus-mediated arrest has not been proven easy, and in most cases the consequences of arrest for the virus life cycle are not well defined. However, a number of effects of arrest are being investigated and it will be interesting to see to what extent perturbation of the G2/M transition is involved in viral infections. Crown Copyright © 2007.




Davy, C., & Doorbar, J. (2007, November 25). G2/M cell cycle arrest in the life cycle of viruses. Virology. https://doi.org/10.1016/j.virol.2007.05.043

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