The Genesis II in primary total knee replacement: A systematic literature review of clinical outcomes

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Since its introduction in 1996, the Genesis II Total Knee System has produced good clinical results in patients undergoing primary total knee replacement. A systematic review of the literature-the first of its kind for this device-was undertaken to collect data on the Genesis II in order to provide a better understanding of its medium- to long-term performance. Of 124 Genesis II-related studies published in the literature, 11 met the eligibility criteria and were included in the final analysis. The included studies had a mean follow-up length of 38.1. months. Data from 1201 knees were available for review. Patients were an average of 70.5. years of age and predominantly female (63%). Findings indicated that the revision rate with this implant is low with up to 11.9. years of follow-up, with 14 revisions in total. The survival rate ranged from 100% at 1 and 2. years to 96.0% at 11.9. years. The mean Knee Society knee score improved 51.0 points from preoperative to postoperative evaluation. In conclusion, the Genesis II exhibited good clinical performance with up to 11. years follow-up, with an encouraging rate of survival and improvement in function. Additional studies with larger sample sizes and longer follow-up periods are needed to better understand the long-term performance of this implant. © 2011 Elsevier B.V..




Bhandari, M., Pascale, W., Sprague, S., & Pascale, V. (2012, January). The Genesis II in primary total knee replacement: A systematic literature review of clinical outcomes. Knee.

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