Genetic Background and the Dilemma of Translating Mouse Studies to Humans

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Abstract

C57BL/6 genetically modified mouse models are the accepted gold standard in biological studies. However, an increasing failure of translating the findings to human (patho)physiology casts doubt on using a single strain to address many questions. © 2008 Elsevier Inc. All rights reserved.

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Rivera, J., & Tessarollo, L. (2008, January 18). Genetic Background and the Dilemma of Translating Mouse Studies to Humans. Immunity. Cell Press. https://doi.org/10.1016/j.immuni.2007.12.008

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