Genomic characterization of a novel human papillomavirus (HPV-117) with a high viral load in a persisting wart

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Abstract

Warts from immunosuppressed organ transplant recipients (OTR) persist over years and may progress into non-melanoma skin cancer. Human papillomaviruses (HPV) are considered the causal agents for the development of such warts. We isolated the novel type HPV-117 from a persisting wart by rolling circle amplification. One hundred eighteen warts from immunocompetent patients (IC) and 49 warts from OTR were analyzed by HPV-117 E6 type-specific PCR. As inferred from a phylogenetic analysis, the new type HPV-117 belonged to alpha-PV species 2, including the most similar types HPV-10 and HPV-94. The general prevalence of HPV-117 in warts was 2% in IC (2/118), and 12% in OTR (6/49). The high viral load in dysplastic cells of a Verruca vulgaris was shown by in situ hybridization. Our results suggest an active role of the novel type in the development of cutaneous warts of OTR. © 2009 Elsevier Inc. All rights reserved.

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Köhler, A., Gottschling, M., Förster, J., Röwert-Huber, J., Stockfleth, E., & Nindl, I. (2010). Genomic characterization of a novel human papillomavirus (HPV-117) with a high viral load in a persisting wart. Virology, 399(1), 129–133. https://doi.org/10.1016/j.virol.2009.12.023

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