Grim19 attenuates DSS induced colitis in an animal model

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Abstract

{D\SS} induced colitis is a chronic inflammatory disease characterized by inflammation in the gastrointestinal tract, which destabilizes the gut and induces an uncontrolled immune response. Although {D\SS} induced colitis is generally thought to develop as a result of an abnormally active intestinal immune system, its pathogenesis remains unclear. Gene associated with retinoid interferon induced mortality (Grim) 19 is an endogenous specific inhibitor of {STAT3}, which regulates the expression of proinflammatory cytokines. In this study, we investigated the influence of {GRIM19} in a {D\SS} induced colitis mouse model. We hypothesized that Grim19 would ameliorate {D\SS} induced colitis by altering {STAT3} activity and intestinal inflammation. Grim19 ameliorated {D\SS} induced colitis severity and protected intestinal tissue. The expression of {STAT3} and proinflammatory cytokines such as {IL}-1βand {TNF}-αin colon and lymph nodes was decreased significantly by Grim19. Moreover, {D\SS} induced colitis progression in a Grim19 transgenic mouse line was inhibited in association with a reduction in {STAT3} and {IL}-17 expression. These results suggest that Grim19 attenuates {D\SS} induced colitis by suppressing the excessive inflammatory response mediated by {STAT3} activation.

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Kim, J. K., Lee, S. H., Lee, S. Y., Kim, E. K., Kwon, J. E., Seo, H. B., … Cho, M. L. (2016). Grim19 attenuates DSS induced colitis in an animal model. PLoS ONE, 11(6). https://doi.org/10.1371/journal.pone.0155853

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