The new monophosphine ligand HandaPhos has been identified such that when complexed in a 1:1 ratio with Pd(OAc)2, enables Pd-catalyzed cross-couplings to be run using ≤1000 ppm of this pre-catalyst. Applications to Suzuki-Miyaura reactions involving highly funtionalized reaction partners are demonstrated, all run using environmentally benign nanoreactors in water at ambient temperatures.
CITATION STYLE
Handa, S., Andersson, M. P., Gallou, F., Reilly, J., & Lipshutz, B. H. (2016). HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium-Catalyzed Cross-Couplings in Water at Room Temperature. Angewandte Chemie - International Edition, 55(16), 4914–4918. https://doi.org/10.1002/anie.201510570
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