The new monophosphine ligand HandaPhos has been identified such that when complexed in a 1:1 ratio with Pd(OAc)2 , enables Pd-catalyzed cross-couplings to be run using ?1000 ppm of this pre-catalyst. Applications to Suzuki– Miyaura reactions involving highly funtionalized reaction partners are demonstrated, all run using environmentally benign nanoreactors in water at ambient temperatures. Com- parisons with existing state-of-the-art ligands and catalysts are discussed herein.
Handa, S., Andersson, M. P., Gallou, F., Reilly, J., & Lipshutz, B. H. (2016). HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium-Catalyzed Cross-Couplings in Water at Room Temperature. Angewandte Chemie - International Edition, 55(16), 4914–4918. https://doi.org/10.1002/anie.201510570