Headache as an initial manifestation of Vogt-Koyanagi-Harada disease

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A 29. year-old healthy Saudi female presented with a 1. week history of headache followed by decreased vision in both eyes. Biomicroscopy revealed anterior uveitis without hypopyon, posterior synechia or keratic precipitate. Fundus examinations were remarkable for serous retinal detachment and hyperemic discs. Fundus fluorescein angiogram showed a hot disc with multiple pinpoint leakage in both eyes. CT scan and MRI were normal, all uveitis workups were negative.Five months later, the patient presented with complete criteria of Vogt-Koyanagi-Harada disease including a 2. weeks history of tinnitus, alopecia, poliosis and vitiligo. Headache alone followed by decreased vision before the onset of neurological and auditory symptoms can be an initial presentation of VKH disease. VKH should be considered in the differential diagnosis of atypical presentation of symptoms.




Khairallah, A. S. (2014). Headache as an initial manifestation of Vogt-Koyanagi-Harada disease. Saudi Journal of Ophthalmology, 28(3), 239–242. https://doi.org/10.1016/j.sjopt.2013.10.003

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