Heparin and carboxymethylchitosan metal nanoparticles: An evaluation of their cytotoxicity

19Citations
Citations of this article
21Readers
Mendeley users who have this article in their library.

Abstract

In the search for noninvasive diagnostic techniques and new therapies, "nanosystems", which are capable of binding and targeting bioactive molecules, are becoming increasingly important. In this context, biocompatible coatings are gaining interest, not only for their biological effects but also because they are considered capable to mask nanoparticle toxicity. In this work, we have compared the toxicity of nanoparticles coated with heparin and carboxymethylchitosan in the SKOV-3 cell line. Our results indicate that heparin and carboxymethylchitosan coatings do not guarantee the decrease of nanoparticle intrinsic toxicity which is often envisaged. Nonetheless, these coatings provide the opportunity for further functionalization with a variety of biomolecules for their use in theranostics. © 2013 Adriana Bava et al.

Cite

CITATION STYLE

APA

Bava, A., Cappellini, F., Pedretti, E., Rossi, F., Caruso, E., Vismara, E., … Gornati, R. (2013). Heparin and carboxymethylchitosan metal nanoparticles: An evaluation of their cytotoxicity. BioMed Research International, 2013. https://doi.org/10.1155/2013/314091

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free