Human CuZn superoxide dismutase enzymatic activity in cells is regulated by the length of the mRNA

14Citations
Citations of this article
8Readers
Mendeley users who have this article in their library.

Abstract

Single functional human CuZnSOD gene encodes two species of mRNA differing in size by 200 nucleotides in the 3′-untranslated region (UTR). We studied the expression of the CuZnSOD cDNA with different 3′- and 5′-UTR. Deletion in the 5′-end does not affect the expression of the enzyme, however, deletion in the 3′-UTR decreases the level of expression of CuZnSOD. The plasmids containing the long CuZnSOD cDNA with all polyadenylation signal sequences utilize primarily the last polyadenylation site and give a long mRNA, which produces three times more enzyme than the short mRNA lacking the last polyadenylation site and the AU-rich region. © 1995.

Author supplied keywords

Cite

CITATION STYLE

APA

Kilk, A., Laan, M., & Torp, A. (1995). Human CuZn superoxide dismutase enzymatic activity in cells is regulated by the length of the mRNA. FEBS Letters, 362(3), 323–327. https://doi.org/10.1016/0014-5793(95)00266-C

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free