Human gut microbes use multiple transporters to distinguish vitamin B 12 analogs and compete in the gut

86Citations
Citations of this article
230Readers
Mendeley users who have this article in their library.

Abstract

Summary Genomic and metagenomic sequencing efforts, including human microbiome projects, reveal that microbes often encode multiple systems that appear to accomplish the same task. Whether these predictions reflect actual functional redundancies is unclear. We report that the prominent human gut symbiont Bacteroides thetaiotaomicron employs three functional, homologous vitamin B12 transporters that in at least two cases confer a competitive advantage in the presence of distinct B12 analogs (corrinoids). In the mammalian gut, microbial fitness can be determined by the presence or absence of a single transporter. The total number of distinct corrinoid transporter families in the human gut microbiome likely exceeds those observed in B. thetaiotaomicron by an order of magnitude. These results demonstrate that human gut microbes use elaborate mechanisms to capture and differentiate corrinoids in vivo and that apparent redundancies observed in these genomes can instead reflect hidden specificities that determine whether a microbe will colonize its host. © 2014 Elsevier Inc.

Cite

CITATION STYLE

APA

Degnan, P. H., Barry, N. A., Mok, K. C., Taga, M. E., & Goodman, A. L. (2014). Human gut microbes use multiple transporters to distinguish vitamin B 12 analogs and compete in the gut. Cell Host and Microbe, 15(1), 47–57. https://doi.org/10.1016/j.chom.2013.12.007

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free