Hyperhomocysteinemia and recurrent early pregnancy loss: A meta-analysis

Citations of this article
Mendeley users who have this article in their library.


Objective: To quantify the risk of recurrent early pregnancy loss in the presence of elevated fasting or afterload homocysteine concentrations or homozygosity for the 677C→T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene (T/T genotype). Design: Case-control studies published between January 1992 and November 1999 were identified with a MEDLINE-search. These studies were combined with a recent case-control study performed by our own research group. Setting: Academic research environment. Patient(s): Studies published in the English language, concerning two or more pregnancy losses before 16 weeks' menstrual age were included. Intervention(s): Meta-analysis of all of the studies included. Main Outcome Measure(s): The number of subjects with and without hyperhomocysteinemia or with the T/T genotype were derived, if necessary the study was supplemented by personal communication with the original authors. Result(s): Pooled risk estimates of 2.7 (1.4 to 5.2) and 4.2 (2.0 to 8.8) were calculated for fasting and afterload plasma homocysteine concentrations, respectively. For the MTHFR T/T genotype a pooled risk estimate of 1.4 (1.0 to 2.0) was found. Conclusion(s): These data support hyperhomocysteinemia as a risk factor for recurrent early pregnancy loss. Further research should be focused on the pathophysiology of this relationship and on the clinical efficacy of B vitamin supplementation. Copyright (C) 2000 American Society for Reproductive Medicine.




Nelen, W. L. D. M., Blom, H. J., Steegers, E. A. P., Den Heijer, M., & Eskes, T. K. A. B. (2000). Hyperhomocysteinemia and recurrent early pregnancy loss: A meta-analysis. Fertility and Sterility, 74(6), 1196–1199. https://doi.org/10.1016/S0015-0282(00)01595-8

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free