Impact of the gut microbiota on chemical risk assessment

0Citations
Citations of this article
16Readers
Mendeley users who have this article in their library.

Abstract

It is well established that the multitude of microbes residing in the human intestine play a key role for health. Recently, it has become apparent that ingested chemicals affect the composition of the human gut microbiota. Additionally, the gut microbes affect the uptake and metabolism of chemicals in multiple ways. Here, we outline the current knowledge about the complex interplay between gut microbes, ingested xenobiotics and toxicological effects. We propose that the intestinal microbiota plays a key role in chemical toxicity, which is typically overlooked in existing approaches for risk assessment. This means that factors such as animal provider, batch/litter differences, and co-caging may significantly influence the outcome of toxicity evaluations based on rodent experiments.

Cite

CITATION STYLE

APA

Licht, T. R., & Bahl, M. I. (2019, June 1). Impact of the gut microbiota on chemical risk assessment. Current Opinion in Toxicology. Elsevier B.V. https://doi.org/10.1016/j.cotox.2018.09.004

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free