Impact of perioperative blood transfusion on clinical outcomes in patients with colorectal liver metastasis after hepatectomy: a meta-analysis

  • Lyu X
  • Qiao W
  • Li D
  • et al.
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Abstract

BACKGROUND: Perioperative blood transfusion may be associated with negative clinical outcomes in oncological surgery. A meta-analysis of published studies was conducted to evaluate the impact of blood transfusion on short-and long-term outcomes following liver resection of colorectal liver metastasis (CLM). MATERIALS AND METHODS: A systematic search was performed to identify relevant articles. Data were pooled for meta-analysis using Review Manager version 5.3. RESULTS: Twenty-five observational studies containing 10621 patients were subjected to the analysis. Compared with non-transfused patients, transfused patients experienced higher overall morbidity (odds ratio {[}OR], 1.98; 95% confidence intervals {[}CI] = 1.49-2.33), more major complications (OR, 2.12; 95% CI = 1.26-3.58), higher mortality (OR, 4.13; 95% CI = 1.96-8.72), and longer length of hospital stay (weighted mean difference, 4.43; 95% CI = 1.15-7.69). Transfusion was associated with reduced overall survival (risk ratio {[}RR], 1.24, 95% CI = 1.11-1.38) and disease-free survival (RR, 1.38, 95% CI= 1.23-1.56). CONCLUSION: Perioperative blood transfusion has a detrimental impact on the clinical outcomes of patients undergoing CLM resection.

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APA

Lyu, X., Qiao, W., Li, D., & Leng, Y. (2017). Impact of perioperative blood transfusion on clinical outcomes in patients with colorectal liver metastasis after hepatectomy: a meta-analysis. Oncotarget, 8(25). https://doi.org/10.18632/oncotarget.16771

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