Inferring carbon sources from gene expression profiles using metabolic flux models

15Citations
Citations of this article
53Readers
Mendeley users who have this article in their library.

Abstract

Bacteria have evolved the ability to efficiently and resourcefully adapt to changing environments. A key means by which they optimize their use of available nutrients is through adjustments in gene expression with consequent changes in enzyme activity. We report a new method for drawing environmental inferences from gene expression data. Our method prioritizes a list of candidate carbon sources for their compatibility with a gene expression profile using the framework of flux balance analysis to model the organism's metabolic network.

Cite

CITATION STYLE

APA

Brandes, A., Lun, D. S., Ip, K., Zucker, J., Colijn, C., Weiner, B., & Galagan, J. E. (2012). Inferring carbon sources from gene expression profiles using metabolic flux models. PLoS ONE, 7(5). https://doi.org/10.1371/journal.pone.0036947

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free