Influence of iron regulation on the metabolome of cryptococcus neoformans

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Abstract

<p>Iron is an essential nutrient for virtually all organisms and acts as a cofactor for many key enzymes of major metabolic pathways. Furthermore, iron plays a critical role in pathogen-host interactions. In this study, we analyzed metabolomic changes associated with iron availability and the iron regulatory protein Cir1 in a human fungal pathogen <italic>Cryptococcus neoformans</italic>. Our metabolite analysis revealed that Cir1 influences the glycolytic pathway, ergosterol biosynthesis and inositol metabolism, which require numerous iron-dependent enzymes and play important roles in pathogenesis and antifungal sensitivity of the fungus. Moreover, we demonstrated that increased cellular iron content and altered gene expression in the <italic>cir1</italic> mutant contributed to metabolite changes. Our study provides a new insight into iron regulation and the role of Cir1 in metabolome of <italic>C. neoformans</italic>.</p>

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Choi, J. N., Kim, J., Kim, J., Jung, W. H., & Lee, C. H. (2012). Influence of iron regulation on the metabolome of cryptococcus neoformans. PLoS ONE, 7(7). https://doi.org/10.1371/journal.pone.0041654

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