Inhibition of sperm glutathione S-transferase leads to functional impairment due to membrane damage

35Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.

Abstract

The role of glutathione S-transferase (GST) in the defense mechanisms of sperm is not known. We report here interference with normal motility, acrosome reaction and fertilizing ability of the goat sperm as a consequence of inhibition of GST activity. That these functional impairments were due to membrane changes was evident from the alteration in the lipid peroxidation status of these cells after GST inhibitor treatment. Increased reactive oxygen species production by the cell which occurred when GST activity was suppressed may be the mediator for membrane damage. The data argue for a role of GST in maintaining sperm membrane status.

Cite

CITATION STYLE

APA

Gopalakrishnan, B., & Shaha, C. (1998). Inhibition of sperm glutathione S-transferase leads to functional impairment due to membrane damage. FEBS Letters, 422(3), 296–300. https://doi.org/10.1016/S0014-5793(98)00032-5

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free