Integrative neuromechanics of crawling in D. Melanogaster Larvae

7Citations
Citations of this article
56Readers
Mendeley users who have this article in their library.

Abstract

Locomotion in an organism is a consequence of the coupled interaction between brain, body and environment. Motivated by qualitative observations and quantitative perturbations of crawling in Drosophila melanogaster larvae, we construct a minimal integrative mathematical model for its locomotion. Our model couples the excitation-inhibition circuits in the nervous system to force production in the muscles and body movement in a frictional environment, thence linking neural dynamics to body mechanics via sensory feedback in a heterogeneous environment. Our results explain the basic observed phenomenology of crawling with and without proprioception, and elucidate the stabilizing role that proprioception plays in producing a robust crawling phenotype in the presence of biological perturbations. More generally, our approach allows us to make testable predictions on the effect of changing body-environment interactions on crawling, and serves as a step in the development of hierarchical models linking cellular processes to behavior.

Cite

CITATION STYLE

APA

Pehlevan, C., Paoletti, P., & Mahadevan, L. (2016). Integrative neuromechanics of crawling in D. Melanogaster Larvae. ELife, 5(2016JULY). https://doi.org/10.7554/eLife.11031

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free